🟩 Pembroxim 100 mg

Generic Name: Pembrolizumab
Brand Name: Pembroxim
Manufacturer: Beacon Pharmaceuticals Ltd.
Dosage Form & Strength: Injection, 100 mg vial
Therapeutic Class: Anticancer | Immune Checkpoint Inhibitor (PD-1 Blocker)

📌 Indications:

Pembroxim (Pembrolizumab) is a monoclonal antibody used in the treatment of multiple advanced cancers. It is indicated for:

• Melanoma (unresectable or metastatic)

• Non-Small Cell Lung Cancer (NSCLC)

• Head & Neck Squamous Cell Carcinoma (HNSCC)

• Classical Hodgkin Lymphoma (cHL)

• Urothelial Carcinoma (Bladder Cancer)

• Renal Cell Carcinoma (RCC)

• Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) cancers

• Cervical Cancer, Gastric Cancer, Esophageal Cancer

• Hepatocellular Carcinoma (HCC) and other PD-L1 expressing tumors

💊 Pharmacology:

• Pembrolizumab is a humanized monoclonal antibody that works as an immune checkpoint inhibitor.

• It binds to the programmed death receptor-1 (PD-1) on T-cells and blocks its interaction with PD-L1 and PD-L2 ligands.

• This releases the “brakes” on the immune system, reactivating T-cell activity against cancer cells.

• The result is enhanced immune response and long-lasting anti-tumor activity.

💉 Dosage & Administration:

• Recommended Dose:

  • 200 mg IV infusion every 3 weeks OR

  • 400 mg IV infusion every 6 weeks

• Administer as an intravenous infusion over 30 minutes.

• Continue until disease progression, unacceptable toxicity, or up to 24 months in certain cases.

• Must be administered under supervision of an oncologist experienced in immunotherapy.

⚠️ Precautions & Warnings:

• Immune-mediated adverse reactions: pneumonitis, colitis, hepatitis, endocrinopathies (thyroid disorders, adrenal insufficiency, diabetes), nephritis, and skin reactions.

• Infusion-related reactions may occur.

• Use with caution in patients with autoimmune diseases or organ transplants.

• Monitor liver, renal, and thyroid function regularly.

❌ Contraindications:

• Hypersensitivity to Pembrolizumab or any excipients.

🤰 Pregnancy & Lactation:

• Pregnancy: May cause fetal harm due to immune activation. Contraception is advised during treatment and for 4 months after the last dose.

• Breastfeeding: Not recommended during therapy.

⚕️ Side Effects:

Common:

• Fatigue, fever

• Cough, shortness of breath

• Rash, itching

• Diarrhea, nausea

• Loss of appetite

Serious (immune-related):

• Pneumonitis

• Severe colitis

• Hepatitis with elevated liver enzymes

• Endocrine disorders (hypothyroidism, hyperthyroidism, adrenal insufficiency, type 1 diabetes)

• Severe skin reactions (Stevens-Johnson Syndrome, toxic epidermal necrolysis)

🧊 Storage Conditions:

• Store refrigerated at 2–8°C.

• Do not freeze or shake.

• Protect from light.

• Diluted solution should be used immediately or stored under recommended conditions.