🟩 Pazonix 200 mg

Generic Name: Pazopanib Hydrochloride
Brand Name: Pazonix
Manufacturer: Beacon Pharmaceuticals Ltd.
Dosage Form & Strength: Tablet, 200 mg
Therapeutic Class: Anticancer | Tyrosine Kinase Inhibitor (TKI)

📌 Indications:

Pazonix (Pazopanib) is indicated for the treatment of advanced cancers, including:

• Renal Cell Carcinoma (RCC): Advanced or metastatic cases.

• Soft Tissue Sarcoma (STS): For patients who have received prior chemotherapy.

• Other off-label uses may include certain rare sarcomas and solid tumors where VEGF inhibition is beneficial.

💊 Pharmacology:

Pazopanib is a multi-targeted tyrosine kinase inhibitor (TKI) that blocks tumor growth and angiogenesis.

• It selectively inhibits receptors such as:

  • VEGFR-1, VEGFR-2, VEGFR-3 (Vascular Endothelial Growth Factor Receptors)

  • PDGFR (Platelet-Derived Growth Factor Receptors)

  • c-Kit and other kinases

• By inhibiting these pathways, Pazonix prevents the development of new blood vessels that tumors need to grow and spread.

• The result is slowed tumor progression and reduced angiogenesis.

💉 Dosage & Administration:

• Recommended Dose: 800 mg orally once daily.

• Tablets should be taken on an empty stomach (at least 1 hour before or 2 hours after a meal).

• Dose adjustments may be required based on tolerability.

• Swallow tablets whole; do not crush or chew.

⚠️ Important: Treatment must be supervised by an oncologist experienced in targeted cancer therapies.

⚠️ Precautions & Warnings:

• Hepatotoxicity: Monitor liver function tests regularly; discontinue if severe hepatic impairment occurs.

• Hypertension: Can occur; blood pressure monitoring is essential.

• Cardiac effects: QT prolongation, heart failure, and arterial thrombotic events possible.

• Hemorrhagic risk & GI perforation: Use with caution in patients at risk.

• Wound healing: Suspend therapy before surgery and resume only after proper healing.

• Proteinuria: Monitor urine protein levels.

❌ Contraindications:

• Hypersensitivity to Pazopanib or any excipients.

• Severe hepatic impairment.

🤰 Pregnancy & Lactation:

• Pregnancy: May cause fetal harm. Effective contraception must be used during treatment and for at least 2 weeks after the final dose.

• Breastfeeding: Not recommended due to potential serious adverse reactions in infants.

⚕️ Side Effects:

Common:

• Hypertension

• Fatigue, weakness

• Diarrhea, nausea, vomiting

• Hair color changes (hypopigmentation)

• Loss of appetite, weight loss

• Headache

Serious:

• Severe liver toxicity

• Cardiac dysfunction, QT prolongation

• Thromboembolic events

• Hemorrhage, GI perforation

• Posterior reversible encephalopathy syndrome (PRES)

🧊 Storage Conditions:

• Store below 30°C, in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.