🟩 Olaparix 150 mg

Generic Name: Olaparib
Brand Name: Olaparix
Manufacturer: Beacon Pharmaceuticals Ltd.
Dosage Form & Strength: Film-coated Tablet, 150 mg
Therapeutic Class: Anticancer | PARP Inhibitor

📌 Indications:

Olaparix (Olaparib) is indicated in the treatment of various advanced cancers, particularly in patients with BRCA gene mutations or those who benefit from PARP inhibition. It is approved for:

• Ovarian Cancer – maintenance therapy for recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients responding to platinum-based chemotherapy.

• Breast Cancer – treatment of HER2-negative metastatic breast cancer with BRCA1/2 mutation.

• Pancreatic Cancer – maintenance therapy for metastatic pancreatic adenocarcinoma with germline BRCA mutation after response to platinum-based chemotherapy.

• Prostate Cancer – treatment of metastatic castration-resistant prostate cancer (mCRPC) with HRR gene mutations including BRCA1/2.

💊 Pharmacology:

Olaparix (Olaparib) is a Poly (ADP-ribose) polymerase (PARP) inhibitor.

• PARP enzymes are essential for repairing single-strand breaks in DNA.

• Inhibition of PARP leads to accumulation of DNA damage.

• In cancer cells with BRCA1/2 mutations (defective homologous recombination repair), this leads to synthetic lethality and cell death.

• Thus, Olaparix selectively targets cancer cells while sparing most normal cells.

💉 Dosage & Administration:

• Recommended Dose: 300 mg (two 150 mg tablets) taken orally twice daily (total daily dose: 600 mg).

• Tablets should be swallowed whole and can be taken with or without food.

• Dose adjustments may be required based on renal impairment, hepatic impairment, or toxicity management.

• Treatment continues until disease progression or unacceptable toxicity.

⚠️ Precautions & Warnings:

• Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML): Rare but serious; monitor blood counts regularly.

• Pneumonitis: Monitor for respiratory symptoms.

• Bone Marrow Suppression: May cause anemia, neutropenia, thrombocytopenia.

• Use caution in patients with renal or hepatic impairment.

• Regular complete blood count (CBC) monitoring is essential.

❌ Contraindications:

• Known hypersensitivity to Olaparib or any excipients.

• Pregnancy & breastfeeding.

🤰 Pregnancy & Lactation:

• Pregnancy: Olaparix may cause fetal harm. Effective contraception required during treatment and for 6 months after last dose.

• Breastfeeding: Contraindicated during therapy and for 1 month after last dose.

⚕️ Side Effects:

Common:

• Fatigue

• Anemia

• Nausea, vomiting

• Dyspepsia, decreased appetite

• Diarrhea, constipation

• Cough, dyspnea

• Headache, dizziness

Serious:

• Myelodysplastic syndrome (MDS)

• Acute Myeloid Leukemia (AML)

• Severe anemia or neutropenia

• Pneumonitis

🧊 Storage Conditions:

• Store below 30°C in a dry place.

• Protect from moisture and light.

• Keep out of reach of children.