🟩 Lazerib 80 mg

Generic Name: Lazeritinib Mesylate Hydrate INN
Brand Name: Lazerib
Manufacturer: Everest Pharmaceuticals Ltd.
Strength & Form: 80 mg | Film-coated tablets
Pack Size: 90 tablets

📌 Indications:

Lazerib (Lazeritinib) is indicated for the treatment of patients with non-small cell lung cancer (NSCLC) that is:

• Locally advanced or metastatic

• Harboring epidermal growth factor receptor (EGFR) mutations

• Especially effective in patients who have developed resistance to previous EGFR-targeted therapies.

💊 Pharmacology:

• Lazeritinib is a third-generation EGFR tyrosine kinase inhibitor (TKI).

• It selectively inhibits both EGFR sensitizing mutations and the T790M resistance mutation, which is the most common cause of acquired resistance to first/second generation TKIs.

• It helps block cancer cell proliferation and promotes apoptosis in tumor cells.

• Lazerib also shows good blood-brain barrier penetration, making it effective against CNS metastases.

💉 Dosage & Administration:

• Recommended dose: 80 mg once daily, orally.

• Can be taken with or without food.

• Treatment should be continued until disease progression or unacceptable toxicity.

⚠️ Tablets should be swallowed whole — not crushed or chewed.

⚠️ Precautions & Warnings:

• Monitor for interstitial lung disease (ILD)/pneumonitis.

• Risk of QT prolongation – ECG monitoring may be required.

• Regular liver function tests recommended.

• Dose adjustments may be necessary in case of toxicity.

❌ Contraindications:

• Hypersensitivity to Lazeritinib or any excipients.

• Not recommended in severe hepatic impairment without careful monitoring.

🤰 Pregnancy & Lactation:

• May cause fetal harm if administered during pregnancy.

• Women of childbearing potential should use effective contraception.

• Not recommended during breastfeeding.

⚕️ Side Effects:

Common:

• Rash, diarrhea, nausea, stomatitis

• Decreased appetite

• Fatigue

• Dry skin and pruritus

Serious:

• Interstitial lung disease/pneumonitis

• QT prolongation and cardiac arrhythmia

• Severe hepatotoxicity

🧊 Storage Conditions:

• Store below 30°C, in a dry place.

• Protect from light and moisture.

• Keep out of reach of children.