Encoraf 75 mg (Encorafenib INN)

Targeted BRAF Inhibitor for Advanced Cancer Therapy

💊 Pharmacology:

Encorafenib is a potent and selective BRAF inhibitor targeting the BRAF V600 mutation, a driver of abnormal cell proliferation in certain cancers. By blocking this pathway, Encoraf®:

• Inhibits tumor cell signaling and growth

• Reduces cancer cell survival

• Enhances effectiveness when combined with MEK or EGFR inhibitors

• Helps delay disease progression

This targeted action provides precision therapy with improved clinical outcomes in mutation-positive tumors.

📌 Indications:

Encoraf® 75 mg is indicated for:

• Unresectable or metastatic melanoma with BRAF V600 mutation (in combination with a MEK inhibitor)

• Metastatic colorectal cancer with BRAF V600 mutation (in combination therapy)

Treatment should be guided by confirmed genetic testing.

💉 Dosage & Administration:

• Dose and schedule must be determined by an oncologist

• Administered orally once daily or as prescribed

• Can be taken with or without food

• Swallow capsules whole with water

• Dose adjustments may be required for toxicity management

Patients should follow prescribed combination therapy protocols strictly.

⚠️ Precautions & Warnings:

Careful monitoring is required during therapy:

• Risk of secondary skin malignancies — regular skin exams recommended

• Cardiac monitoring when used in combination regimens

• Liver function monitoring advised

• Watch for signs of bleeding or vision disturbances

• Sun sensitivity — protective measures recommended

Promptly report unusual symptoms to healthcare providers.

❌ Contraindications:

• Known hypersensitivity to Encorafenib or formulation components

🤰 Pregnancy & Lactation:

• May cause fetal harm — avoid use during pregnancy

• Effective contraception required during treatment

• Breastfeeding should be discontinued during therapy and for a recommended time after last dose

⚕️ Side Effects:

Common side effects may include:

• Fatigue

• Nausea

• Abdominal pain

• Joint pain

• Rash

• Diarrhea

• Hair thinning

Serious but less common effects:

• Skin cancers

• Cardiac rhythm changes

• Liver abnormalities

• Severe bleeding

🧊 Storage Conditions:

• Store below 30°C

• Protect from moisture and direct sunlight

• Keep in original packaging

• Keep out of reach of children